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Transient effect of mossy fiber stimulation on spatial firing of CA3 neurons

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Title
Transient effect of mossy fiber stimulation on spatial firing of CA3 neurons
Author(s)
Joonyeup Lee; Miru Yun; Eunjae Cho; Jong Won Lee; Doyun Lee; Min Whan Jung
Publication Date
2019-07
Journal
HIPPOCAMPUS, v.29, no.7, pp.639 - 651
Publisher
WILEY
Abstract
Strong hippocampal mossy fiber synapses are thought to function as detonators, imposing "teaching" signals onto CA3 neurons during new memory formation. For an empirical test of this long-standing view, we examined effects of optogenetically stimulating mossy fibers on spatial firing of CA3 neurons in freely-moving mice. We found that spatially restricted mossy fiber stimulation drives novel place-specific firing in some CA3 pyramidal neurons. Such neurons comprise only a minority, however, and many more CA3 neurons showed inhibited spatial firing during mossy fiber stimulation. Also, changes in spatial firing induced by mossy fiber stimulation, both activated and inhibited, reverted immediately upon stimulation termination, leaving CA3 place fields unaltered. Our results do not support the traditional view that mossy fibers impose teaching signals onto CA3 network, and show robustness of established CA3 spatial representations. © 2019 Wiley Periodicals, Inc.
URI
https://pr.ibs.re.kr/handle/8788114/6148
ISSN
1050-9631
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Social Neuroscience Group(사회성 뇌과학 그룹) > Journal Papers (저널논문)
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
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