Highly regioselective and sustainable solar click reaction: a new post- synthetic modified triazole organic polymer as a recyclable photocatalyst for regioselective azide- alkyne cycloaddition reaction

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Title
Highly regioselective and sustainable solar click reaction: a new post- synthetic modified triazole organic polymer as a recyclable photocatalyst for regioselective azide- alkyne cycloaddition reaction
Author(s)
Dolly Yadav; Nem Singh; Tae Wu Kim; Jae Young Kim; No-Joong Park; Jin-Ook Baeg
Publication Date
2019-05
Journal
GREEN CHEMISTRY, v.21, no.10, pp.2677 - 2685
Publisher
ROYAL SOC CHEMISTRY
Abstract
The synthesis of pharmaceutically active 1,2,3-triazoles has been continuously scrutinized in the search for unique and effective catalysts to make the process efficient, green, and sustainable. Here, we are presenting a new visible light active Ni(ii) cyclam-integrated triazole-linked organic polymer (Ni-TLOP) photocatalyst for the synthesis of 1,2,3-triazole compounds with excellent efficiency and regioselectivity. The reaction was studied for a series of substrates and the absolute regioselectivity of a representative triazole product has also been confirmed by X-ray crystallography. The proficiency and chemical orthogonality of the Ni-TLOP are remarkable and it shows enhanced efficiency and regioselectivity. The use of a recyclable photocatalyst and non-hazardous reagents makes the catalytic system sustainable and environmentally friendly. This photocatalyzed click reaction technique has been successfully applied to the expedient synthesis of one of the most sold anti-epileptic drugs rufinamide. © The Royal Society of Chemistry 2019
URI
https://pr.ibs.re.kr/handle/8788114/6102
ISSN
1463-9262
Appears in Collections:
Center for Nanomaterials and Chemical Reactions(나노물질 및 화학반응 연구단) > Journal Papers (저널논문)
Files in This Item:
Green Chem., 2019, 21, 2677.pdfDownload

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