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인지 및 사회성 연구단
인지 및 사회성 연구단
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Neuronal calcium channel alpha(1) subunit interacts with AMPA receptor, increasing its cell surface localisation

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Title
Neuronal calcium channel alpha(1) subunit interacts with AMPA receptor, increasing its cell surface localisation
Author(s)
Bo Am Seo; Jung-Ha Lee; Ho Min Kim; Myoung-Goo Kang
Publication Date
2018-04
Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.498, no.3, pp.402 - 408
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Abstract
Voltage-activated Ca2+ channels (Ca-v) play critical roles in excitable cells including neurons. Unlike the well-defined roles of Ca(v)2 for pre-synaptic neurotransmission, the post-synaptic function of Ca(v)2 is unclear. Based on our previous study demonstrating the postsynaptic association of the Ca(v)2 with the AMPA receptor (AMPA-R), in this study we sought to further analyse the Ca(v)2-AMPA-R association. We used a step-by-step dissociation of partially purified native Ca(v)2-AMPA-R complexes and co-immunoprecipitation of the Ca(v)2-AMPA-R complexes expressed in HEK293T cells to demonstrate that the main subunit of Ca-v, alpha(1), formed a complex with the AMPA-R without the auxiliary subunits beta, alpha(2)delta, gamma(2/3). The alpha(1) subunit increased the cell-surface localisation of the AMPA-R, which could be a post-synaptic function of the Ca(v)2. (C) 2018 Elsevier Inc. All rights reserved
URI
https://pr.ibs.re.kr/handle/8788114/6055
ISSN
0006-291X
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
Pioneer Research Center for Biomolecular and Cellular Structure(바이오분자 및 세포구조 연구단) > Protein Communication Group(단백질 커뮤니케이션 그룹) > Journal Papers (저널논문)
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