Microbial Colonization at Early Life Promotes the Development of Diet-Induced CD8 alpha beta Intraepithelial T Cells

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Title
Microbial Colonization at Early Life Promotes the Development of Diet-Induced CD8 alpha beta Intraepithelial T Cells
Author(s)
Jisun Jung; Charles D. Surh; You Jeong Lee
Publication Date
2019-04
Journal
MOLECULES AND CELLS, v.42, no.4, pp.313 - 320
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Abstract
Intraepithelial lymphocytes (IELs) develop through the continuous interaction with intestinal antigens such as commensal microbiome and diet. However, their respective roles and mutual interactions in the development of IELs are largely unknown. Here, we showed that dietary antigens regulate the development of the majority of CD8 alpha ss IELs in the small intestine and the absence of commensal microbiota particularly during the weaning period, delay the development of IELs. When we tested specific dietary components, such as wheat or combined corn, soybean and yeast, they were dependent on commensal bacteria for the timely development of diet-induced CD8 alpha ss IELs. In addition, supplementation of intestinal antigens later in life was inefficient for the full induction of CD8 alpha ss IELs. Overall, our findings suggest that early exposure to commensal bacteria is important for the proper development of dietary antigen-dependent immune repertoire in the gut.
URI
https://pr.ibs.re.kr/handle/8788114/5984
ISSN
1016-8478
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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