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Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors

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Title
Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors
Author(s)
Sumit Barua; Jong Youl Kim; Jae Young Kim; Jae Hwan Kim; Jong Eun Lee
Publication Date
2019-04
Journal
NEUROCHEMICAL RESEARCH, v.44, no.4, pp.735 - 750
Publisher
SPRINGER/PLENUM PUBLISHERS
Abstract
The central nervous system (CNS) is the most injury-prone part of the mammalian body. Any acute or chronic, central or peripheral neurological disorder is related to abnormal biochemical and electrical signals in the brain cells. As a result, ion channels and receptors that are abundant in the nervous system and control the electrical and biochemical environment of the CNS play a vital role in neurological disease. The N-methyl-d-aspartate receptor, 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl) propanoic acid receptor, kainate receptor, acetylcholine receptor, serotonin receptor, 2-adrenoreceptor, and acid-sensing ion channels are among the major channels and receptors known to be key components of pathophysiological events in the CNS. The primary amine agmatine, a neuromodulator synthesized in the brain by decarboxylation of l-arginine, can regulate ion channel cascades and receptors that are related to the major CNS disorders. In our previous studies, we established that agmatine was related to the regulation of cell differentiation, nitric oxide synthesis, and murine brain endothelial cell migration, relief of chronic pain, cerebral edema, and apoptotic cell death in experimental CNS disorders. In this review, we will focus on the pathophysiological aspects of the neurological disorders regulated by these ion channels and receptors, and their interaction with agmatine in CNS injury © Springer Science+Business Media, LLC, part of Springer Nature 2019
URI
https://pr.ibs.re.kr/handle/8788114/5866
ISSN
0364-3190
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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