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Ni-Mediated Generation of cN Unit from Formamide and Its Catalysis in the Cyanation Reactions

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Title
Ni-Mediated Generation of cN Unit from Formamide and Its Catalysis in the Cyanation Reactions
Author(s)
Luo Yang; Yu-Ting Liu; Yoonsu Park; Sung-Woo Park; Sukbok Chang
Subject
alkynes, ; aryl halides, ; cyano source, ; formamide, ; hydrocyanation, ; Ni catalyst
Publication Date
2019-04
Journal
ACS CATALYSIS, v.9, no.4, pp.3360 - 3365
Publisher
AMER CHEMICAL SOC
Abstract
The in situ generation of a cyano unit from readily available organic precursors is of high interest in synthetic chemistry. Herein, we report the first example of Ni-mediated dehydration of formamide to form CN and its subsequent catalytic applications in the hydrocyanation of alkynes and cyanation of aryl halides. Formamide can serve as a convenient source for the nitrile unit, in that it releases water as the only byproduct. © 2019 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/5815
DOI
10.1021/acscatal.8b05111
ISSN
2155-5435
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
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