Structural and dynamic views of the CRISPR-Cas system at the single-molecule level

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Title
Structural and dynamic views of the CRISPR-Cas system at the single-molecule level
Author(s)
Seung Hwan Lee; Bae S.
Publication Date
2016-04
Journal
BMB REPORTS, v.49, no.4, pp.201 - 207
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Abstract
The CRISPR-Cas system has emerged as a fascinating and important genome editing tool. It is now widely used in biology, biotechnology, and biomedical research in both academic and industrial settings. To improve the specificity and efficiency of Cas nucleases and to extend the applications of these systems for other areas of research, an understanding of their precise working mechanisms is crucial. In this review, we summarize current studies on the molecular structures and dynamic functions of type I and type II Cas nucleases, with a focus on target DNA searching and cleavage processes as revealed by single-molecule observations. © 2016 by the The Korean Society for Biochemistry and Molecular Biology
URI
https://pr.ibs.re.kr/handle/8788114/5807
ISSN
1976-6696
Appears in Collections:
Center for Genome Engineering(유전체 교정 연구단) > Journal Papers (저널논문)
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