Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex Highly Cited Paper

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Title
Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex
Author(s)
Kragel, PA; Kano, M; Van Oudenhove, L; Ly, HG; Dupont, P; Rubio, A; Delon-Martin, C; Bonaz, BL; Manuck, SB; Gianaros, PJ; Ceko, M; Losin, EAR; Woo, CW; Nichols, TE; Wager, TD
Publication Date
2018-02
Journal
NATURE NEUROSCIENCE, v.21, no.2, pp.283 - 289
Publisher
NATURE PUBLISHING GROUP
Abstract
The medial frontal cortex, including anterior midcingulate cortex, has been linked to multiple psychological domains, including cognitive control, pain, and emotion. However, it is unclear whether this region encodes representations of these domains that are generalizable across studies and subdomains. Additionally, if there are generalizable representations, do they reflect a single underlying process shared across domains or multiple domain-specific processes? We decomposed multivariate patterns of functional MRI activity from 270 participants across 18 studies into study-specific, subdomain-specific, and domain-specific components and identified latent multivariate representations that generalized across subdomains but were specific to each domain. Pain representations were localized to anterior midcingulate cortex, negative emotion representations to ventromedial prefrontal cortex, and cognitive control representations to portions of the dorsal midcingulate. These findings provide evidence for medial frontal cortex representations that generalize across studies and subdomains but are specific to distinct psychological domains rather than reducible to a single underlying process. © 2017 The Author(s)
URI
https://pr.ibs.re.kr/handle/8788114/5795
ISSN
1097-6256
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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