Chemical exchange saturation transfer imaging of phosphocreatine in the muscle

Cited 0 time in webofscience Cited 0 time in scopus
7 Viewed 3 Downloaded
Title
Chemical exchange saturation transfer imaging of phosphocreatine in the muscle
Author(s)
Julius Juhyun Chung; Tao Jin; Jung Hee Lee; Seong‐Gi Kim
Publication Date
2019-06
Journal
MAGNETIC RESONANCE IN MEDICINE, v.81, no.6, pp.3476 - 3487
Publisher
WILEY-BLACKWELL
Abstract
Purpose To determine the exchange parameters for the CEST of phosphocreatine (PCrCEST) in phantoms and to characterize PCrCEST in vivo in the muscle at different saturation powers and magnetic fields. Methods Exchange parameters were measured in PCr solutions using varying saturation power at 15.2 T. Z‐spectra were analyzed using multipool Lorentzian fitting in the hindlimb using various powers at 2 different fields: 9.4 T and 15.2 T. Modulation of PCr signal in PCrCEST and phosphorus MRS was observed in the mouse hindlimb before and after euthanasia. Results The exchange rate of PCr at physiological pH in phantoms was confirmed to be in a much slower exchange regime compared with Cr: kex at pH 7.3 and below was less than 400 s–1. There was insufficient signal for detection of PCrCEST in the brain, but PCrCEST in the hindlimb was measured to be 2.98% ± 0.43 at a B1 of 0.47 μT at 15.2 T, which is 29% higher than 9.4T values. The value of PCrCEST at a B1 of 0.71 μT was not significantly different than that measured at a B1 of 0.47 μT. After euthanasia, PCrCEST signal dropped by 82.3% compared with an 85% decrease in PCr in phosphorus MRS, whereas CrCEST signal increased by 90.6%. Conclusion The PCrCEST technique has viable sensitivity in the muscle at high fields and shows promise for the study of metabolic dysfunction and cardiac systems. © 2019 International Society for Magnetic Resonance in Medicine
URI
https://pr.ibs.re.kr/handle/8788114/5635
ISSN
0740-3194
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
Files in This Item:
15 정주현_Chemical exchange saturation transfer imaging of phosphocreatine in the muscle.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse