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유전체 교정 연구단
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Species-wide genetic incompatibility analysis identifies immune genes as hot spots of deleterious epistasis

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Title
Species-wide genetic incompatibility analysis identifies immune genes as hot spots of deleterious epistasis
Author(s)
Chae E.; Bomblies K.; Sang-Tae Kim; Karelina D.; Zaidem M.; Ossowski S.; Martín-Pizarro C.; Laitinen R.A.E.; Rowan B.A.; Tenenboim H.; Lechner S.; Demar M.; Habring-Müller A.; Lanz C.; Rätsch G.; Weigel D.
Publication Date
2014-12
Journal
CELL, v.159, no.6, pp.1341 - 1351
Publisher
CELL PRESS
Abstract
Intraspecific genetic incompatibilities prevent the assembly of specific alleles into single genotypes and influence genome- and species-wide patterns of sequence variation. A common incompatibility in plants is hybrid necrosis, characterized by autoimmune responses due to epistatic interactions between natural genetic variants. By systematically testing thousands of F1 hybrids of Arabidopsis thaliana strains, we identified a small number of incompatibility hot spots in the genome, often in regions densely populated by nucleotide-binding domain and leucine-rich repeat (NLR) immune receptor genes. In several cases, these immune receptor loci interact with each other, suggestive of conflict within the immune system. A particularly dangerous locus is a highly variable cluster of NLR genes, DM2, which causes multiple independent incompatibilities with genes that encode a range of biochemical functions, including NLRs. Our findings suggest that deleterious interactions of immune receptors limit the combinations of favorable disease resistance alleles accessible to plant genomes. © 2014 Elsevier Inc
URI
https://pr.ibs.re.kr/handle/8788114/5623
ISSN
0092-8674
Appears in Collections:
Center for Genome Engineering(유전체 교정 연구단) > Journal Papers (저널논문)
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