Ru(II)-based antineoplastic: A "wingtip" N-heterocyclic carbene facilitates access to a new class of organometallics that are cytotoxic to common cancer cell lines

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Title
Ru(II)-based antineoplastic: A "wingtip" N-heterocyclic carbene facilitates access to a new class of organometallics that are cytotoxic to common cancer cell lines
Author(s)
Ambarish Mondal; Rajat K. Tripathy; Parul Dutta; Manas Kumar Santra; Anvarhusein A. Isab; Christopher W. Bielawski; Hemanta K. Kisan; Swapan K. Chandra; Joydev Dinda
Publication Date
2019-01
Journal
APPLIED ORGANOMETALLIC CHEMISTRY, v.33, no.1, pp.e4692 -
Publisher
JOHN WILLEY AND SONS LTD
Abstract
The syntheses, structures, and chemotherapeutic activities of Ag(I)-, Au(I)-, and Ru(II)-complexes ligated to a novel N-heterocyclic carbene ligand, 2-(4-nitrophenyl)imidazo[1,5-a]pyridin-2-ylidene (1), are described. The corresponding complexes, [Ag(1)(2)][PF6], [Au(1)(2)][PF6] (3), and [Ru(1)(p-cymene)Cl][PF6] (4), were prepared using convenient transmetallation chemistry and characterized using a range of spectroscopic and analytical techniques. X-ray crystallography revealed that complexes 2 and 3 adopted linear structures whereas 4 exhibited a prototypical "piano-stool"-like geometry; the structural assignments were further supported by DFT calculations. A series of in vitro studies revealed that while the aforementioned Ag(I), Au(I) and Ru(II) complexes exhibited significant cytotoxicities against the human colon adenocarcinoma (HCT 116), lung cancer (A549), and breast cancer (MCF7) cell lines, the Ru derivative was most prominent. © 2018 John Wiley & Sons, Ltd.
URI
https://pr.ibs.re.kr/handle/8788114/5603
ISSN
0268-2605
Appears in Collections:
Center for Multidimensional Carbon Materials(다차원 탄소재료 연구단) > Journal Papers (저널논문)
Files in This Item:
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