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분자 분광학 및 동력학 연구단
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Senescent tumor cells building three-dimensional tumor clusters

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Title
Senescent tumor cells building three-dimensional tumor clusters
Author(s)
Hyun-Gyu Lee; June Hoan Kim; Woong Sun; Sung-Gil Chi; Wonshik Choi; Kyoung J. Lee
Publication Date
2018-07
Journal
SCIENTIFIC REPORTS, v.8, no.1, pp.10503 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Cellular senescence, a permanent cell-cycle arrest, is a common yet intriguing phenomenon, in which its beneficial significance for biological organisms has only begun to be explored. Among others, senescent cells are able to transform tissue structures around them. Tumor cells, whose hallmark is their ability to proliferate indefinitely, are not free from the phenomenon. Here, we report a remarkable observation where senescent cells in a dense mono-layer of breast cancer colony act as aggregating centers for non-senescent cells in their vicinity. Consequently, the senescent cells actively form localized 3D cell-clusters in a confluent 2D tumor layer. The biophysical mechanism underpinning the surprising phenomenon primarily involves mitotic cell-rounding, dynamic and differential cell attachments, and cellular chemotaxis. By incorporating these few biophysical factors, we were able to recapitulate the experimental observation via a cellular Potts Model.© The Author(s) 2018
URI
https://pr.ibs.re.kr/handle/8788114/5556
ISSN
2045-2322
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > Journal Papers (저널논문)
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