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Christopher W Bielawski
다차원 탄소재료 연구단
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Isoelectronic Pt(ii)- and Au(iii)-N-heterocyclic carbene complexes: A structural and biological comparison

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Title
Isoelectronic Pt(ii)- and Au(iii)-N-heterocyclic carbene complexes: A structural and biological comparison
Author(s)
Bidyut Kumar Rana; Snehasis Mishra; Deblina Sarkar; Tapan Kumar Mondal; Saikat K. Seth; Valerio Bertolasi; Krishna Das Saha; Christopher W. Bielawski; Anvarhusein A. Isab; Joydev Dinda
Publication Date
2018-07
Journal
NEW JOURNAL OF CHEMISTRY, v.42, no.13, pp.10704 - 10711
Publisher
ROYAL SOC CHEMISTRY
Abstract
To elucidate the intrinsic biological activities displayed by platinum versus gold-based organometallic reagents, the isoelectronic and isostructural square planar complexes [Pt(C∩N)(C)Cl][PF6] (2) and [Au(C∩N)(C)Cl][PF6]2 (3), which are supported by a common N-heterocyclic carbene, 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylidene (1), were synthesized. The complexes were characterized using a range of spectroscopic techniques as well as single crystal X-ray diffraction and a series of computational studies were also performed to gain additional insight into their fundamental electronic bonding structures. The cytotoxicities of the complexes were tested in vitro against non-small lung carcinoma (A549), colorectal carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines. The measured IC50 values showed that the Au(iii)-NHC complex is more potent than its Pt analogue. © 2018 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique
URI
https://pr.ibs.re.kr/handle/8788114/5537
ISSN
1144-0546
Appears in Collections:
Center for Multidimensional Carbon Materials(다차원 탄소재료 연구단) > Journal Papers (저널논문)
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