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Christopher W Bielawski
다차원 탄소재료 연구단
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Synthesis and cytotoxic characteristics displayed by a series of Ag(i)-, Au(i)- and Au(III)-complexes supported by a common N-heterocyclic carbene

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Title
Synthesis and cytotoxic characteristics displayed by a series of Ag(i)-, Au(i)- and Au(III)-complexes supported by a common N-heterocyclic carbene
Author(s)
Lalmohan Jhulki; Parul Dutta; Manas Kumar Santra; Marlon H. Cardoso; Karen G. N. Oshiro; Octavio L. Franco; Valerio Bertolasi; Anvarhusein A. Isab; Christopher W. Bielawski; Joydev Dinda
Publication Date
2018-08
Journal
NEW JOURNAL OF CHEMISTRY, v.42, no.16, pp.13948 - 13956
Publisher
ROYAL SOC CHEMISTRY
Abstract
The synthesis, structures and anticancer studies of a series of precious metal complexes supported by 1-methyl-2-(phenyl)imidazo[1,5-a]pyridine-2-ylidene (1) have been highlighted. The Ag(i) (2), Au(i) (3) and Au(iii) (4) complexes were prepared using standard methods and characterized by a range of techniques, including NMR spectroscopy, X-ray crystallography and elemental analyses. The in vitro cytotoxicity activities displayed by 2-4 were explored against human colon adenocarcinoma (HCT116), lung cancer (A549) and breast cancer (MCF7) cell lines. A series of assays showed that all of the complexes exhibited significant growth inhibition in the aforementioned cell lines. Inspection of the data collected revealed that the Au(i) and Ag(i) complexes were more potent than their Au(iii) congener, a trend that was found to be consistent with molecular docking studies that utilized BCL-2 as a model as this protein regulates cell death through apoptosis. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique ©The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2018 New J. Chem., 2018
URI
https://pr.ibs.re.kr/handle/8788114/5531
ISSN
1144-0546
Appears in Collections:
Center for Multidimensional Carbon Materials(다차원 탄소재료 연구단) > Journal Papers (저널논문)
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