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식물 노화·수명 연구단
식물 노화·수명 연구단
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Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C-elegans

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Title
Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C-elegans
Author(s)
Heehwa G. Son; Keunhee Seo; Mihwa Seo; Sangsoon Park; Seokjin Ham; Seon Woo A. An; Eun-Seok Choi; Yujin Lee; Haeshim Baek; Eunju Kim; Youngjae Ryu; Chang Man Ha; Ao-Lin Hsu; Tae-Young Roh; Sung Key Jang; Seung-Jae V. Lee
Publication Date
2018-12
Journal
GENES & DEVELOPMENT, v.32, no.23-24, pp.1562 - 1575
Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Abstract
Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS © 2018 Son et al.
URI
https://pr.ibs.re.kr/handle/8788114/5376
ISSN
0890-9369
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
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