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Radiomics features to distinguish glioblastoma from primary central nervous system lymphoma on multi-parametric MRI

Cited 1 time in webofscience Cited 10 time in scopus
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Title
Radiomics features to distinguish glioblastoma from primary central nervous system lymphoma on multi-parametric MRI
Author(s)
Yikyung Kim; Hwan-ho Cho; Sung Tae kim; Hyunjin Park; Dohyun Nam; Doo-Sik Kong
Subject
Glioblastoma, ; Lymphoma, ; Machine learning, ; Magnetic resonance imaging, ; Diagnosis
Publication Date
2018-12
Journal
NEURORADIOLOGY, v.60, no.12, pp.1297 - 1305
Publisher
SPRINGER
Abstract
Retrospective evaluation of data was approved by the local ethics committee and informed consent was waived. A total of 143 patients (two independent cohorts for discovery [n = 86; glioblastoma = 49, PCNSL = 37] and validation [n = 57; glioblastoma = 29, PCNSL = 28]) with newly diagnosed glioblastoma and PCNSL were subjected to radiomics analysis using the multi-parametric MRI (contrast-enhanced T1-weighted imaging, T2-weighted imaging, and diffusion-weighted imaging). Radiomics analyses were performed for two types of regions of interest (ROI) covering contrast-enhancing tumor and whole (enhancing or non-enhancing) tumor plus peritumoral edema. A total of 127 radiomics features were calculated. Feature selection was performed to identify the most discriminating features for every MR image in the discovery cohort. The identified features were used to calculate radiomics scores, which were later used in logistic regression to distinguish between PCNSL and glioblastoma. The classification model was further tested on the independent validation cohort. Results Fifteen features were selected as significant features in the discovery cohort. Using the identified features and calculated radiomics scores, the logistic regression-based classifier yielded an area under the curve (AUC) of 0.979, sensitivity of 0.938, and specificity of 0.944 in the discovery cohort to distinguish between glioblastoma and PCNSL. A similarly high rate of performance was observed in the validation cohort (AUC = 0.956) (c) Springer-Verlag GmbH Germany, part of Springer Nature 2018
URI
https://pr.ibs.re.kr/handle/8788114/5349
DOI
10.1007/s00234-018-2091-4
ISSN
0028-3940
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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