Single-Chain Atomic Crystals as Extracellular Matrix-Mimicking Material with Exceptional Biocompatibility and Bioactivity

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Title
Single-Chain Atomic Crystals as Extracellular Matrix-Mimicking Material with Exceptional Biocompatibility and Bioactivity
Author(s)
Jin Woong Lee; Sudong Chae; Seoungbae Oh; Si Hyun Kim; Kyung Hwan Choi; Montri Meeseepong; Jongwha Chang; Namsoo Kim; Yong Ho Kim; Nae-Eung Lee; Jung Heon Lee; Jae-Young Choi
Publication Date
2018-12
Journal
NANO LETTERS, v.18, no.12, pp.7619 - 7627
Publisher
AMER CHEMICAL SOC
Abstract
In this study, Mo3Se3 - single-chain atomic crystals (SCACs) with atomically small chain diameters of ��0.6 nm, large surface areas, and mechanical flexibility were synthesized and investigated as an extracellular matrix (ECM)-mimicking scaffold material for tissue engineering applications. The proliferation of L-929 and MC3T3-E1 cell lines increased up to 268.4 �� 24.4% and 396.2 �� 8.1%, respectively, after 48 h of culturing with Mo3Se3 - SCACs. More importantly, this extremely high proliferation was observed when the cells were treated with 200 ��g mL-1 of Mo3Se3 - SCACs, which is above the cytotoxic concentration of most nanomaterials reported earlier. An ECM-mimicking scaffold film prepared by coating Mo3Se3 - SCACs on a glass substrate enabled the cells to adhere to the surface in a highly stretched manner at the initial stage of cell adhesion. Most cells cultured on the ECM-mimicking scaffold film remained alive; in contrast, a substantial number of cells cultured on glass substrates without the Mo3Se3 - SCAC coating did not survive. This work not only proves the exceptional biocompatible and bioactive characteristics of the Mo3Se3 - SCACs but also suggests that, as an ECM-mimicking scaffold material, Mo3Se3 - SCACs can overcome several critical limitations of most other nanomaterials. c. 2018 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/5313
ISSN
1530-6984
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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