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분자 분광학 및 동력학 연구단
분자 분광학 및 동력학 연구단
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In-Situ Measurement of Vitamin C Content in Commercial Tablet Products by Terahertz Time-Domain

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Title
In-Situ Measurement of Vitamin C Content in Commercial Tablet Products by Terahertz Time-Domain
Author(s)
JuHee Kang; Jeonghun Song; Tae Sub Jung; Kyungwon Kwak; Hyang Sook Chun
Publication Date
2018-04
Journal
JOURNAL OF INFRARED MILLIMETER AND TERAHERTZ WAVES, v.39, no.4, pp.367 - 377
Publisher
SPRINGER
Abstract
Terahertz time-domain spectroscopy (THz-TDS) was applied to investigate the feasibility of in-situ measuring vitamin C content in commercial tablet products without any pretreatments. Characteristic absorption peaks of vitamin C were analyzed with quantum mechanical calculation to reveal the molecular origin of them. The peak appearing at 1.08 THz was then selected and tested for its suitability as a fingerprint signal for analyzing the vitamin C content in dietary supplement tablets. There are a couple of factors influencing THz absorbance other than concentration. Among those, the effects of tablet thickness and types of excipients in the tablet products were found to be significant, and were corrected with the calibration curve to determine vitamin C concentration in tablet forms. Furthermore, commercial tablet products in the market were analyzed using THz-TDS and the measured vitamin C contents were in good agreement with those determined using a reference method (high-performance liquid chromatography). Thus, our results suggest that THz-TDS can be used for the in-situ analysis of vitamin C in commercial tablet products. (c) Springer Science+Business Media, LLC, part of Springer Nature 2018
URI
https://pr.ibs.re.kr/handle/8788114/5290
ISSN
1866-6892
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > Journal Papers (저널논문)
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