Eukaryotic DNA damage responses: Homologous recombination factors and ubiquitin modification

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Title
Eukaryotic DNA damage responses: Homologous recombination factors and ubiquitin modification
Author(s)
Nam soo Lee; Soomi Kim; Yong Woo Jung; Hongtae Kim
Publication Date
2018-05
Journal
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, v.809, no., pp.88 - 98
Publisher
ELSEVIER SCIENCE BV
Abstract
To prevent genomic instability disorders, cells have developed a DNA damage response. The response involves various proteins that sense damaged DNA, transduce damage signals, and effect DNA repair. In addition, ubiquitin modifications modulate the signaling pathway depending on cellular context. Among various types of DNA damage, double-stranded breaks are highly toxic to genomic integrity. Homologous recombination (HR) repair is an essential mechanism that fixes DNA damage because of its high level of accuracy. Although factors in the repair pathway are well established, pinpointing the exact mechanisms of repair and devising therapeutic applications requires more studies. Moreover, essential functions of ubiquitin modification in the DNA damage signaling pathway have emerged. In this review, to explore the eukaryotic DNA damage response, we will mention the functions of main factors in the HR repair pathway and ubiquitin modification © 2017 Elsevier B.V.
URI
https://pr.ibs.re.kr/handle/8788114/5276
ISSN
0027-5107
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
Files in This Item:
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