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A novel mechanism of regulation of SHPRH by circular RNA, circ-SHPRH in glioblastoma

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Title
A novel mechanism of regulation of SHPRH by circular RNA, circ-SHPRH in glioblastoma
Author(s)
Shinseog Kim; Soomin Kim; Yuri Seo; Kyung Jae Myung
Publication Date
2018-06
Journal
NON-CODING RNA INVESTIGATION, v.2, no., pp.31 -
Publisher
AME Publishing Company
Abstract
Maintenance of genomic integrity is critical for the control of cell proliferation and survival. The genome is susceptible to DNA damage, which generates DNA lesions blocking the progression of DNA replication. Cells have multiple mechanisms to respond to DNA damage during replication; stabilization of the stalled replication fork, bypass the damage using specific DNA polymerases or recombination, or converting the damage into a second lesion. Responses by cells to DNA damage by these mechanisms can either activate DNA-repair pathway or programmed cell death (1). Failure or abnormal responses to DNA damage results in accumulation of mutations and promotes transformation of normal cells into cancer cells. © Non-coding RNA Investigation. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/5267
ISSN
2522-6673
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > Journal Papers (저널논문)
Files in This Item:
2018_NCRI_A novel mechanism of regulation of SHPRH by circular RNA, circ-SHPRH in glioblastom_Shinseog Kim.pdfDownload

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