Structural Basis for LAR-RPTP-Mediated Synaptogenesis

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Title
Structural Basis for LAR-RPTP-Mediated Synaptogenesis
Author(s)
Seoung Youn Won; Ho Min Kim
Publication Date
2018-07
Journal
MOLECULES AND CELLS, v.41, no.7, pp.622 - 630
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Abstract
Leukocyte common antigen-related protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that regulate neurite outgrowth and neuronal regeneration. LAR-RPTPs have also received particular attention as the major presynaptic hubs for synapse organization through selective binding to numerous postsynaptic adhesion partners. Recent structural studies on LAR-RPTP-mediated trans-synaptic adhesion complexes have provided significant insight into the molecular basis of their specific interactions, the key codes for their selective binding, as well as the higher-order clustering of LAR-RPTPs necessary for synaptogenic activity. In this review, we summarize the structures of LAR-RPTPs in complex with various postsynaptic adhesion partners and discuss the molecular mechanisms underlying LAR-RPTP-mediated synaptogenesis. (c) The Korean Society for Molecular and Cellular Biology. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/5260
ISSN
1016-8478
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
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