Structural Basis for LAR-RPTP-Mediated Synaptogenesis
DC Field | Value | Language |
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dc.contributor.author | Seoung Youn Won | - |
dc.contributor.author | Ho Min Kim | - |
dc.date.available | 2019-01-03T05:33:47Z | - |
dc.date.created | 2018-11-22 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/5260 | - |
dc.description.abstract | Leukocyte common antigen-related protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that regulate neurite outgrowth and neuronal regeneration. LAR-RPTPs have also received particular attention as the major presynaptic hubs for synapse organization through selective binding to numerous postsynaptic adhesion partners. Recent structural studies on LAR-RPTP-mediated trans-synaptic adhesion complexes have provided significant insight into the molecular basis of their specific interactions, the key codes for their selective binding, as well as the higher-order clustering of LAR-RPTPs necessary for synaptogenic activity. In this review, we summarize the structures of LAR-RPTPs in complex with various postsynaptic adhesion partners and discuss the molecular mechanisms underlying LAR-RPTP-mediated synaptogenesis. (c) The Korean Society for Molecular and Cellular Biology. All rights reserved. | - |
dc.description.uri | 1 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.subject | heparan sulfate | - |
dc.subject | higher-order clustering | - |
dc.subject | LAR-RPTPs | - |
dc.subject | LAR-RPTP?mediated trans-synaptic adhesion complex | - |
dc.subject | synaptic adhesion molecules | - |
dc.title | Structural Basis for LAR-RPTP-Mediated Synaptogenesis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000440656500002 | - |
dc.identifier.scopusid | 2-s2.0-85056272325 | - |
dc.identifier.rimsid | 66200 | - |
dc.contributor.affiliatedAuthor | Ho Min Kim | - |
dc.identifier.doi | 10.14348/molcells.2018.0202 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.41, no.7, pp.622 - 630 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 41 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 622 | - |
dc.citation.endPage | 630 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | PROTEIN-TYROSINE-PHOSPHATASES | - |
dc.subject.keywordPlus | SYNAPTIC ADHESION MOLECULES | - |
dc.subject.keywordPlus | RAT HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | PTP-SIGMA | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | TRANSSYNAPTIC INTERACTION | - |
dc.subject.keywordPlus | INTERLEUKIN-1 RECEPTOR | - |
dc.subject.keywordPlus | MENTAL-RETARDATION | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | heparan sulfate | - |
dc.subject.keywordAuthor | higher-order clustering | - |
dc.subject.keywordAuthor | LAR-RPTPs | - |
dc.subject.keywordAuthor | LAR-RPTP-mediated trans-synaptic adhesion complex | - |
dc.subject.keywordAuthor | synaptic adhesion molecules | - |