Synergistic Ensemble of Optogenetic Actuators and Dynamic Indicators in Cell Biology.

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Title
Synergistic Ensemble of Optogenetic Actuators and Dynamic Indicators in Cell Biology.
Author(s)
Jihoon Kim; Won Do Heo
Publication Date
2018-09
Journal
MOLECULES AND CELLS, v.41, no.9, pp.809 - 817
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Abstract
Discovery of the naturally evolved fluorescent proteins and their genetically engineered biosensors have enormously contributed to current bio-imaging techniques. These reporters to trace dynamic changes of intracellular protein activities have continuously transformed according to the various demands in biological studies. Along with that, light-inducible optogenetic technologies have offered scientists to perturb, control and analyze the function of intracellular machineries in spatio-temporal manner. In this review, we present an overview of the molecular strategies that have been exploited for producing genetically encoded protein reporters and various optogenetic modules. Finally, in particular, we discuss the current efforts for combined use of these reporters and optogenetic modules as a powerful tactic for the control and imaging of signaling events in cells and tissues. (c) The Korean Society for Molecular and Cellular Biology. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/5188
ISSN
1016-8478
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
Files in This Item:
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