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면역 미생물 공생 연구단
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T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells

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Title
T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells
Author(s)
Hye-Ran Kim; YeVin Mun; Kyung-Sik Lee; Yoo-Jin Park; Jeong-Su Park; Jin-Hwa Park; Bu-Nam Jeon; Chang-Hyun Kim; Youngsoo Jun; Young-Min Hyun; Minsoo Kim; Sang-Myeong Lee; Chul-Seung Park; Sin-Hyeog Im; Chang-Duk Jun
Publication Date
2018-09
Journal
Nature Communications, v.9, no.1, pp.3630 -
Publisher
NATURE PUBLISHING GROUP, MACMILLAN
Abstract
Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear. Here we show that antigen-specific T cells deposit membrane particles derived from microvilli onto the surface of cognate antigen-bearing APCs. Microvilli carry T cell receptors (TCR) at all stages of T cell activation and are released as large TCR-enriched, T cell microvilli particles (TMP) in a process of trogocytosis. These microvilli exclusively contain protein arrestin-domain-containing protein 1, which is directly involved in membrane budding and, in combination with vacuolar protein-sorting-associated protein 4, transforms large TMPs into smaller, exosome-sized TMPs. Notably, TMPs from CD4+ T cells are enriched with LFA-2/CD2 and various cytokines involved in activating dendritic cells. Collectively, these results demonstrate that T cell microvilli constitute “immunological synaptosomes” that carry T cell messages to APCs. © 2018, The Author(s)
URI
https://pr.ibs.re.kr/handle/8788114/5187
ISSN
2041-1723
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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