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유전체 항상성 연구단
유전체 항상성 연구단
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The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation

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Title
The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation
Author(s)
Ho-Soo Lee; Zhonghui Lin; Sunyoung Chae; Young-Suk Yoo; Byung-Gyu Kim; Youngsoo Lee; Jared L. Johnson; You-Sun Kim; Lewis C. Cantley; Chang-Woo Lee; Hongtao Yu; Hyeseong Cho
Publication Date
2018-09
Journal
NATURE COMMUNICATIONS, v.9, no.1, pp.3848 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Chromatin remodelers regulate the nucleosome barrier during transcription, DNA replication, and DNA repair. The chromatin remodeler RSF1 is enriched at mitotic centromeres, but the functional consequences of this enrichment are not completely understood. Shugoshin (Sgo1) protects centromeric cohesion during mitosis and requires BuB1-dependent histone H2A phosphorylation (H2A-pT120) for localization. Loss of Sgo1 at centromeres causes chromosome missegregation. Here, we show that RSF1 regulates Sgo1 localization to centromeres through coordinating a crosstalk between histone acetylation and phosphorylation. RSF1 interacts with and recruits HDAC1 to centromeres, where it counteracts TIP60-mediated acetylation of H2A at K118. This deacetylation is required for the accumulation of H2A-pT120 and Sgo1 deposition, as H2A-K118 acetylation suppresses H2A-T120 phosphorylation by Bub1. Centromeric tethering of HDAC1 prevents premature chromatid separation in RSF1 knockout cells. Our results indicate that RSF1 regulates the dynamics of H2A histone modifications at mitotic centromeres and contributes to the maintenance of chromosome stability
URI
https://pr.ibs.re.kr/handle/8788114/5174
ISSN
2041-1723
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > Journal Papers (저널논문)
Files in This Item:
2018_NATURE COM._The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation.pdfDownload

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