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A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles

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Title
A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles
Author(s)
Sehyun Chae; Su-Jin Kim; Young Do Koo; Jung Hwa Lee; Hokeun Kim; Byung Yong Ahn; Yong-Chan Ha; Yong-Hak Kim; Mi Gyeong Jang; Kyung-Hoi Koo; Sung Hee Choi; Soo Lim; Young Joo Park; Hak Chul Jang; Daehee Hwang; Sang-Won Lee; Kyong Soo Park
Publication Date
2018-09
Journal
EXPERIMENTAL AND MOLECULAR MEDICINE, v.50, no., pp.129 -
Publisher
NATURE PUBLISHING GROUP
Abstract
The pathogenesis of type 2 diabetes mellitus (T2DM) is closely associated with mitochondrial functions in insulin-responsive tissues. The mitochondrial proteome, compared with the mitochondrial genome, which only contains 37 genes in humans, can provide more comprehensive information for thousands of mitochondrial proteins regarding T2DM-associated mitochondrial functions. However, T2DM-associated protein signatures in insulin-responsive tissues are still unclear. Here, we performed extensive proteome profiling of mitochondria from skeletal muscles in nine T2DM patients and nine nondiabetic controls. A comparison of the mitochondrial proteomes identified 335 differentially expressed proteins (DEPs) between T2DM and nondiabetic samples. Functional and network analyses of the DEPs showed that mitochondrial metabolic processes were downregulated and mitochondria-associated ER membrane (MAM) processes were upregulated. Of the DEPs, we selected two (NDUFS3 and COX2) for downregulated oxidative phosphorylation and three (CALR, SORT, and RAB1A) for upregulated calcium and protein transport as representative mitochondrial and MAM processes, respectively, and then confirmed their differential expression in independent mouse and human samples. Therefore, we propose that these five proteins be used as a potential protein profile that is indicative of the dysregulation of mitochondrial functions in T2DM, representing downregulated oxidative phosphorylation and upregulated MAM functions. © The Author(s) 2018
URI
https://pr.ibs.re.kr/handle/8788114/5171
ISSN
1226-3613
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
Files in This Item:
Exp Mol Med. 50(9). 129 (2018).pdfDownload

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