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Pulmonary pericytes regulate lung morphogenesis

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Title
Pulmonary pericytes regulate lung morphogenesis
Author(s)
Kato K.; Diéguez-Hurtado R.; Do Young Park; Seon Pyo Hong; Kato-Azuma S.; Adams S.; Stehling M.; Trappmann B.; Wrana J.L.; Gou Young Koh; Adams R.H.
Publication Date
2018-06
Journal
Nature Communications, v.9, no., pp.2448 -
Publisher
Springer Nature
Abstract
Blood vessels are essential for blood circulation but also control organ growth, homeostasis, and regeneration, which has been attributed to the release of paracrine signals by endothelial cells. Endothelial tubules are associated with specialised mesenchymal cells, termed pericytes, which help to maintain vessel wall integrity. Here we identify pericytes as regulators of epithelial and endothelial morphogenesis in postnatal lung. Mice lacking expression of the Hippo pathway components YAP and TAZ in pericytes show defective alveologenesis. Mutant pericytes are present in normal numbers but display strongly reduced expression of hepatocyte growth factor leading to impaired activation of the c-Met receptor, which is expressed by alveolar epithelial cells. YAP and TAZ are also required for expression of angiopoietin-1 by pulmonary pericytes, which also controls hepatocyte growth factor expression and thereby alveologenesis in an autocrine fashion. These findings establish that pericytes have important, organ-specific signalling properties and coordinate the behavior of epithelial and vascular cells during lung morphogenesis. © 2018 The Author(s)
URI
https://pr.ibs.re.kr/handle/8788114/4975
ISSN
2041-1723
Appears in Collections:
Center for Cardiovascular Research(혈관 연구단) > Journal Papers (저널논문)
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