Chemoselective Tyrosine Bioconjugation through Sulfate Click Reaction

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Title
Chemoselective Tyrosine Bioconjugation through Sulfate Click Reaction
Author(s)
Choi, EJ; Jung, D; Jong-Seo Kim; Lee, Y; Kim, BM
Publication Date
2018-08
Journal
CHEMISTRY-A EUROPEAN JOURNAL, v.24, no.43, pp.10948 - 10952
Publisher
WILEY-V C H VERLAG GMBH
Abstract
A novel and selective tyrosine functionalization strategy through SuFEx (sulfur fluoride exchange) chemistry is presented. In this approach, free tyrosine (Tyr) reacts selectively with aryl fluorosulfate in the presence of various nucleophilic amino acid residues in bio-tolerable conditions. Chemoselectivity of this unique SuFEx reaction was confirmed in amino acid, peptide, and protein conjugations. The functions of peptides and proteins were well-preserved as demonstrated from the Tyr-specific modification of cell-penetrating peptide and erythropoietin. This method is well-suited for residue-specific modification of native proteins, and thus would expand the versatility of bio-conjugation in protein chemistry. (c) 2018 Wiley-VCH Verlag GmbH & Co. KGaA
URI
https://pr.ibs.re.kr/handle/8788114/4938
ISSN
0947-6539
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
Files in This Item:
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