BROWSE

Related Scientist

rna's photo.

rna
rna연구단
more info

ITEM VIEW & DOWNLOAD

Chemoselective Tyrosine Bioconjugation through Sulfate Click Reaction

Cited 7 time in webofscience Cited 7 time in scopus
821 Viewed 185 Downloaded
Title
Chemoselective Tyrosine Bioconjugation through Sulfate Click Reaction
Author(s)
Choi, EJ; Jung, D; Jong-Seo Kim; Lee, Y; Kim, BM
Subject
bioconjugation, ; chemoselectivity, ; fluorosulfate, ; SuFEx, ; tyrosine
Publication Date
2018-08
Journal
CHEMISTRY-A EUROPEAN JOURNAL, v.24, no.43, pp.10948 - 10952
Publisher
WILEY-V C H VERLAG GMBH
Abstract
A novel and selective tyrosine functionalization strategy through SuFEx (sulfur fluoride exchange) chemistry is presented. In this approach, free tyrosine (Tyr) reacts selectively with aryl fluorosulfate in the presence of various nucleophilic amino acid residues in bio-tolerable conditions. Chemoselectivity of this unique SuFEx reaction was confirmed in amino acid, peptide, and protein conjugations. The functions of peptides and proteins were well-preserved as demonstrated from the Tyr-specific modification of cell-penetrating peptide and erythropoietin. This method is well-suited for residue-specific modification of native proteins, and thus would expand the versatility of bio-conjugation in protein chemistry. (c) 2018 Wiley-VCH Verlag GmbH & Co. KGaA
URI
https://pr.ibs.re.kr/handle/8788114/4938
DOI
10.1002/chem.201802380
ISSN
0947-6539
Appears in Collections:
Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
Choi_et_al-2018-Chemistry_-_A_European_Journal.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse