Asymmetric C-H Functionalization of Cyclopropanes Using an Isoleucine-NH2 Bidentate Directing Group

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Title
Asymmetric C-H Functionalization of Cyclopropanes Using an Isoleucine-NH2 Bidentate Directing Group
Author(s)
Jinhee Kim; Mikyung Sim; Namhoon Kim; Sungwoo Hong
Publication Date
2015-10
Journal
SYNTHESIS-STUTTGART, v.47, no.19, pp.A136 - A139
Publisher
GEORG THIEME VERLAG KG
Abstract
The systematic investigation of substrate-bound a-amino acid auxiliaries has resulted in catalytic asymmetric C–H functionalization of cyclopropanes enabled by amino acid amides as chiral bidentate directing groups. The use of an Ile-NH2 auxiliary embedded in the substrate provided excellent levels of asymmetric induction (diastereomeric ratio of up to 72 : 1) in the Pd(II)-catalyzed b-methylene C(sp3)–H bond activation of cyclopropanes and cross-coupling with aryl iodides. This journal is © The Royal Society of Chemistry 2015
URI
https://pr.ibs.re.kr/handle/8788114/4851
ISSN
0039-7881
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > Journal Papers (저널논문)
Files in This Item:
H_s-0035-1560166_Asymmetric C-H foundation_페이지 기사.pdfDownload

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