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Transcription factor KLF10 constrains IL-17-committed Vγ4+ γδ T cells

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Title
Transcription factor KLF10 constrains IL-17-committed Vγ4+ γδ T cells
Author(s)
Girak Kim; Min Jeong Gu; Soo Ji Kim; Kwang Hyun Ko; Yoon-Chul Kye; Cheol Gyun Kim; Jae-Ho Cho; Woon-Kyu Lee; Ki-Duk Song; Hyuk Chu; Yeong-Min Park; Seung Hyun Han; Cheol-Heui Yun
Publication Date
2018-02
Journal
Frontiers in Immunology, v.9, no.196, pp.1 - 15
Publisher
FRONTIERS MEDIA SA
Abstract
γδ T cells, known to be an important source of innate IL-17 in mice, provide critical contributions to host immune responses. Development and function of γδ T cells are directed by networks of diverse transcription factors (TFs). Here, we examine the role of the zinc finger TFs, Kruppel-like factor 10 (KLF10), in the regulation of IL-17-committed CD27- γδ T (γδ27--17) cells. We found selective augmentation of Vγ4+ γδ27- cells with higher IL-17 production in KLF10-deficient mice. Surprisingly, KLF10-deficient CD127hi Vγ4+ γδ27--17 cells expressed higher levels of CD5 than their wild-type counterparts, with hyper-responsiveness to cytokine, but not T-cell receptor, stimuli. Thymic maturation of Vγ4+ γδ27- cells was enhanced in newborn mice deficient in KLF10. Finally, a mixed bone marrow chimera study indicates that intrinsic KLF10 signaling is requisite to limit Vγ4+ γδ27--17 cells. Collectively, these findings demonstrate that KLF10 regulates thymic development of Vγ4+ γδ27- cells and their peripheral homeostasis at steady state. © 2018 Kim, Gu, Kim, Ko, Kye, Kim, Cho, Lee, Song, Chu, Park, Han and Yun
URI
https://pr.ibs.re.kr/handle/8788114/4683
ISSN
1664-3224
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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