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면역미생물공생연구단
면역 미생물 공생 연구단
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Emerging functions of regulatory T cells in tissue homeostasis

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Title
Emerging functions of regulatory T cells in tissue homeostasis
Author(s)
Amit Sharma; Dipayan Rudra
Publication Date
2018-04
Journal
Frontiers in Immunology, v.9, no., pp.1 - 26
Publisher
FRONTIERS MEDIA SA
Abstract
CD4+Foxp3+ regulatory T-cells (Tregs) are a unique subset of helper T-cells, which regulate immune response and establish peripheral tolerance. Tregs not only maintain the tone and tenor of an immune response by dominant tolerance but, in recent years, have also been identified as key players in resolving tissue inflammation and as mediators of tissue healing. Apart from being diverse in their origin (thymic and peripheral) and location (lymphoid and tissue resident), Tregs are also phenotypically heterogeneous as per the orientation of ongoing immune response. In this review, we discuss the recent advances in the field of Treg biology in general, and non-lymphoid and tissue-resident Tregs in particular. We elaborate upon well-known visceral adipose tissue, colon, skin, and tumor-infiltrating Tregs and newly identified tissue Treg populations as in lungs, skeletal muscle, placenta, and other tissues. Our attempt is to differentiate Tregs based on distinctive properties of their location, origin, ligand specificity, chemotaxis, and specific suppressive mechanisms. Despite ever expanding roles in maintaining systemic homeostasis, Tregs are employed by large varieties of tumors to dampen antitumor immunity. Thus, a comprehensive understanding of Treg biology in the context of inflammation can be instrumental in effectively managing tissue transplantation, autoimmunity, and antitumor immune responses. © 2018 Sharma and Rudra
URI
http://pr.ibs.re.kr/handle/8788114/4593
DOI
10.3389/fimmu.2018.00883
ISSN
1664-3224
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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