BROWSE

Related Scientist

Researcher

RNA 연구단
RNA 연구단
more info

PARN and TOE1 Constitute a 3 ' End Maturation Module for Nuclear Non-coding RNAs

Cited 0 time in webofscience Cited 0 time in scopus
83 Viewed 37 Downloaded
Title
PARN and TOE1 Constitute a 3 ' End Maturation Module for Nuclear Non-coding RNAs
Author(s)
Ahyeon Son; Jong-Eun Park; VN Kim
Publication Date
2018-04
Journal
CELL REPORTS, v.23, no.3, pp.888 - 898
Publisher
CELL PRESS
Abstract
Poly(A)-specific ribonuclease (PARN) and target of EGR1 protein 1 (TOE1) are nuclear granule-associated deadenylases, whose mutations are linked to multiple human diseases. Here, we applied mTAIL-seq and RNA sequencing (RNA-seq) to systematically identify the substrates of PARN and TOE1 and elucidate their molecular functions. We found that PARN and TOE1 do not modulate the length of mRNA poly(A) tails. Rather, they promote the maturation of nuclear small non-coding RNAs (ncRNAs). PARN and TOE1 act redundantly on some ncRNAs, most prominently small Cajal body-specific RNAs (scaRNAs). scaRNAs are strongly downregulated when PARN and TOE1 are compromised together, leading to defects in small nuclear RNA (snRNA) pseudouridylation. They also function redundantly in the biogenesis of telomerase RNA component (TERC), which shares sequence motifs found in H/ACA box scaRNAs. Our findings extend the knowledge of nuclear ncRNA biogenesis, and they provide insights into the pathology of PARN/TOE1-associated genetic disorders whose therapeutic treatments are currently unavailable (c) 2018 The Author(s).
URI
http://pr.ibs.re.kr/handle/8788114/4564
ISSN
2211-1247
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
Files in This Item:
PIIS2211124718304509.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse