Revisiting of Pd Nanoparticles in Cancer Treatment: All-Round Excellence of Porous Pd Nanoplates in Gene-Thermo Combinational Therapy

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Title
Revisiting of Pd Nanoparticles in Cancer Treatment: All-Round Excellence of Porous Pd Nanoplates in Gene-Thermo Combinational Therapy
Author(s)
Kang S.; Shin W.; Kang K.; Choi M.-H.; Kim Y.-J.; Kim Y.-K.; Dal-Hee Min; Jang H.
Publication Date
2018-04
Journal
ACS Applied Materials and Interfaces, v.10, no.16, pp.13819 - 13828
Publisher
ACS Publications
Abstract
Gold nanomaterials are commonly used in biomedical applications owing to their excellent biocompatibility and unique physicochemical and optical properties, whereas Pd nanomaterials are mainly used as catalysts. Here, we re-examined the possible applications of Pd nanomaterials. Reducing agent-assisted excessive galvanic replacement-mediated porous Au nanoplates, porous Pt nanoplates, and porous Pd nanoplate synthesis enabled us to compare the properties and efficiency of nanoplates composed of three metal elements (Au, Pt, and Pd). According to our analytical results, porous Pd nanoplates exhibited exceptional all-round excellence in photothermal conversion, therapeutic gene loading/releasing, cytotoxicity, and in vitro combination cancer treatment. We believe that this discovery broadens the potential applications of metal nanomaterials, with an emphasis on more efficient biomedical applications in limited conventional fields. © 2018 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/4555
ISSN
1944-8244
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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