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Time-evolving genetic networks reveal a NAC troika that negatively regulates leaf senescence in Arabidopsis

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Title
Time-evolving genetic networks reveal a NAC troika that negatively regulates leaf senescence in Arabidopsis
Author(s)
Hyo Jung Kim; Ji-Hwan Park; Jingil Kim; Jung Ju Kim; Sunghyun Hong; Jeongsik Kim; Jin Hee Kim; Hye Ryun Woo; Changbong Hyeon; Pyung Ok Lim; Hong Gil Nam; Daehee Hwang
Publication Date
2018-05
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-PHYSICAL SCIENCES, v.115, no.21, pp.E4930 - E4939
Publisher
NATL ACAD SCIENCES
Abstract
Senescence is controlled by time-evolving networks that describe the temporal transition of interactions among senescence regulators. Here, we present time-evolving networks for NAM/ATAF/CUC (NAC) transcription factors in Arabidopsis during leaf aging. The most evident characteristic of these time-dependent networks was a shift from positive to negative regulation among NACs at a presenescent stage. ANAC017, ANAC082, and ANAC090, referred to as a "NAC troika," govern the positive-to-negative regulatory shift. Knockout of the NAC troika accelerated senescence and the induction of other NACs, whereas overexpression of the NAC troika had the opposite effects. Transcriptome and molecular analyses revealed shared suppression of senescence-promoting processes by the NAC troika, including salicylic acid (SA) and reactive oxygen species (ROS) responses, but with predominant regulation of SA and ROS responses by ANAC090 and ANAC017, respectively. Our time-evolving networks provide a unique regulatory module of presenescent repressors that direct the timely induction of senescence-promoting processes at the presenescent stage of leaf aging.
URI
http://pr.ibs.re.kr/handle/8788114/4548
ISSN
0027-8424
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
Files in This Item:
PNAS_Vol. 115(21) pp. E4930-E4939.pdfDownload

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