TCR tuning of T cell subsets

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Title
TCR tuning of T cell subsets
Author(s)
Jae-Ho Cho; Jonathan Sprent
Publication Date
2018-05
Journal
IMMUNOLOGICAL REVIEWS, v.283, no.1, pp.129 - 137
Publisher
John Wiley & Sons Ltd
Abstract
After selection in the thymus, the post-thymic T cell compartments comprise heterogenous subsets of naive and memory T cells that make continuous T cell receptor (TCR) contact with self-ligands bound to major histocompatibility complex (MHC) molecules. T cell recognition of self-MHC ligands elicits covert TCR signaling and is particularly important for controlling survival of naive T cells. Such tonic TCR signaling is tightly controlled and maintains the cells in a quiescent state to avoid autoimmunity. Here, we review how naive and memory T cells are differentially tuned and wired for TCR sensitivity to self and foreign ligands © 2018 John Wiley & Sons A/S.
URI
https://pr.ibs.re.kr/handle/8788114/4538
ISSN
0105-2896
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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