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Sex hormones establish a reserve pool of adult muscle stem cells

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Title
Sex hormones establish a reserve pool of adult muscle stem cells
Author(s)
Kim, JH; Han, GC; Seo, JY; Park, I; Park, W; Jeong, HW; Lee, SH; Bae, SH; Seong, J; Yum, MK; Hann, SH; Kwon, YG; Daekwan Seo; Choi, MH; Kong, YY
Publication Date
2016-09
Journal
NATURE CELL BIOLOGY, v.18, no.9, pp.930 - 940
Publisher
NATURE PUBLISHING GROUP
Abstract
Quiescent satellite cells, known as adult muscle stem cells, possess a remarkable ability to regenerate skeletal muscle following injury throughout life. Although they mainly originate from multipotent stem/progenitor cells of the somite, the mechanism underlying the establishment of quiescent satellite cell populations is unknown. Here, we show that sex hormones induce Mind bomb 1 (Mib1) expression in myofibres at puberty, which activates Notch signalling in cycling juvenile satellite cells and causes them to be converted into adult quiescent satellite cells. Myofibres lacking Mib1 fail to send Notch signals to juvenile satellite cells, leading to impaired cell cycle exit and depletion. Our findings reveal that the hypothalamic-pituitary-gonadal axis drives Mibi expression in the myofibre niche. Moreover, the same axis regulates the re-establishment of quiescent satellite cell populations following injury. Our data show that sex hormones establish adult quiescent satellite cell populations by regulating the myofibre niche at puberty and re-establish them during regeneration © 2016 Macmillan Publishers Limited, part of springer Nature All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/4465
ISSN
1465-7392
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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