BROWSE

Related Scientist

cnir's photo.

cnir
뇌과학이미징연구단
more info

ITEM VIEW & DOWNLOAD

Regulation of Chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis

Cited 23 time in webofscience Cited 24 time in scopus
971 Viewed 296 Downloaded
Title
Regulation of Chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
Author(s)
Do-Hyun Kim; Hong-Jai Park; Sangho Lim; Ja-Hyun Koo; Hong-Gyun Lee; Jin Ouk Choi; Ji Hoon Oh; Sang-Jun Ha; Min-Jong Kang; Chang-Min Lee; Chun Geun Lee; Jack A. Elias; Je-Min Choi
Publication Date
2018-02
Journal
NATURE COMMUNICATIONS, v.9, no.1, pp.503
Publisher
NATURE PUBLISHING GROUP
Abstract
Chitinase-3-like-1 (Chi3l1) is known to play a significant role in the pathogenesis of Type 2 inflammation and cancer. However, the function of Chi3l1 in T cell and its clinical implications are largely unknown. Here we show that Chi3l1 expression was increased in activated T cells, especially in Th2 cells. In addition, Chi3l1-deficient T cells are hyper-responsive to TcR stimulation and are prone to differentiating into Th1 cells. Chi3l1-deficient Th1 cells show increased expression of anti-tumor immunity genes and decreased Th1 negative regulators. Deletion of Chi3l1 in T cells in mice show reduced melanoma lung metastasis with increased IFNγ and TNFα-producing T cells in the lung. Furthermore, silencing of Chi3l1 expression in the lung using peptide-siRNA complex (dNP2-siChi3l1) efficiently inhibit lung metastasis with enhanced Th1 and CTL responses. Collectively, this study demonstrates Chi3l1 is a regulator of Th1 and CTL which could be a therapeutic target to enhance anti-tumor immunity.
URI
https://pr.ibs.re.kr/handle/8788114/4446
DOI
10.1038/s41467-017-02731-6
ISSN
2041-1723
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
Regulation of Chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis_최제민.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse