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Synthesis of Fluorescent Au Nanocrystals-Silica Hybrid Nanocomposite (FLASH) with Enhanced Optical Features for Bioimaging and Photodynamic Activity

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Title
Synthesis of Fluorescent Au Nanocrystals-Silica Hybrid Nanocomposite (FLASH) with Enhanced Optical Features for Bioimaging and Photodynamic Activity
Author(s)
Taeshik Kim; Hongje Jang; Seongchan Kim; Jong-Hwan Lee; Sung-Yon Kim; Noo Li Jeon; Joon Myong Song; Dal-Hee Min
Publication Date
2018-01
Journal
LANGMUIR, v.34, no.1, pp.173 - 178
Publisher
AMER CHEMICAL SOC
Abstract
Fluorescent Au nanocrystals (AuNCs)-silica hybrid nanocomposite (FLASH) was synthesized by co-condensation of surface-modified AuNCs. Present FLASH nanocomposite exhibited four times the enhanced photoluminescence and photocatalytic activity compared to single nanocrystals. On the basis of these enhanced optical features, we successfully demonstrated in vitro fluorescence bioimaging of introduced FLASH to human cervical cancer cell line (HeLa). Beyond the confirmation of photocatalytic activity from the photodegradation of methylene blue as a model compound, the regional selective photodynamic therapy of HeLa cells under UV irradiation was also presented. Taken together the enhanced optical features and further potential in theranostic applications, we expect that the present FLASH can be a promising tool for nanobiotechnology field. © 2017 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/4325
ISSN
0743-7463
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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