Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases Highly Cited Paper

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Title
Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases
Author(s)
Kyunghee Byun; YongCheol Yoo; Myeongjoo Son; Jaesuk Lee; Goo-Bo Jeong; Young Mok Park; Ghasem Hosseini Salekdeh; Bonghee Lee
Publication Date
2017-09
Journal
PHARMACOLOGY & THERAPEUTICS, v.177, no., pp.44 - 55
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Abstract
Advanced glycation end products (AGEs) and their receptor have been implicated in the progressions of many intractable diseases, such as diabetes and atherosclerosis, and are also critical for pathologic changes in chronic degenerative diseases, such as Alzheimer's disease, Parkinson's disease, and alcoholic brain damage. Recently activated macrophages were found to be a source of AGEs, and the most abundant form of AGEs, AGE-albumin excreted by macrophages has been implicated in these diseases and to act through common pathways. AGEs inhibition has been shown to prevent the pathogenesis of AGEs-related diseases in human, and therapeutic advances have resulted in several agents that prevent their adverse effects. Recently, anti-inflammatory molecules that inhibit AGEs have been shown to be good candidates for ameliorating diabetic complications as well as degenerative diseases. This review was undertaken to present, discuss, and clarify current understanding regarding AGEs formation in associationwithmacrophages, different diseases, therapeutic and diagnostic strategy and links with RAGE inhibition. © 2017 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
URI
https://pr.ibs.re.kr/handle/8788114/4268
ISSN
0163-7258
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
Files in This Item:
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