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식물 노화·수명 연구단
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The Protein Trio RPK1-CaM4-RbohF Mediates Transient Superoxide Production to Trigger Age-Dependent Cell Death in Arabidopsis

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Title
The Protein Trio RPK1-CaM4-RbohF Mediates Transient Superoxide Production to Trigger Age-Dependent Cell Death in Arabidopsis
Author(s)
Ja Choon Koo; In Chul Lee; Cheng Dai; Yuree Lee; Hui Kyung Cho; Yumi Kim; Bong-Kwan Phee; Hyunmin Kim; Il Hwan Lee; Seung Hee Choi; Su Jin Park; In Seon Jeon; Hong Gil Nam; June M. Kwak
Publication Date
2017-12
Journal
Cell Reports, v.21, no.12, pp.3373 - 3380
Publisher
Cell Press
Abstract
Reactive oxygen species (ROS) are inevitable byproducts of aerobic metabolic processes, causing non-specific oxidative damage and also acting as second messengers. Superoxide is a short-lived ROS that functions in various cellular responses, including aging and cell death. However, it is unclear as to how superoxide brings about age-dependent cell death and senescence. Here, we show that the accumulation and signaling of superoxide are mediated by three Arabidopsis proteins—RPK1, CaM4, and RbohF—which trigger subsequent cellular events leading to age-dependent cell death. We demonstrate that the NADPH oxidase RbohF is responsible for RPK1-mediated transient accumulation of superoxide, SIRK kinase induction, and cell death, all of which are positively regulated by CaM4. RPK1 physically interacts with and phosphorylates CaM4, which, in turn, interacts with RbohF. Overall, we demonstrate how the protein trio governs the superoxide accumulation and signaling at the cell surface to control senescence and cell death. (c) 2017 The Authors.
URI
http://pr.ibs.re.kr/handle/8788114/4189
DOI
10.1016/j.celrep.2017.11.077
ISSN
2211-1247
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
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