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SHPRH as a new player in ribosomal RNA transcription and its potential role in homeostasis of ribosomal DNA repeats

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Title
SHPRH as a new player in ribosomal RNA transcription and its potential role in homeostasis of ribosomal DNA repeats
Author(s)
Deokjae Lee; Jun Hong Park; Shinseog Kim; Seon-gyeong Lee; Kyungjae Myung
Publication Date
2018-05
Journal
Transcription, v.9, no.3, pp.190 - 195
Publisher
Taylor and Francis Ltd.
Abstract
There are hundreds of copies of rDNA repeats in mammalian chromosomes and the ratio of active, poised, or inactive rDNA is regulated in epigenetic manners. Recent studies demonstrated that a post-DNA replication repair enzyme, SHPRH affects rRNA transcription by recognizing epigenetic markers on rDNA promoters and unveiled potential links between DNA repair and ribosome biogenesis. This study suggests that SHPRH could be a link between mTOR-mediated epigenetic regulations and rRNA transcription, while concomitantly affecting genomic integrity. ⓒ 2017, ⓒ 2016 Taylor & Francis.regulations and rRNA transcription, while concomitantly affecting genomic integrity.
URI
https://pr.ibs.re.kr/handle/8788114/4187
ISSN
2154-1264
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > Journal Papers (저널논문)
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