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SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner

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Title
SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner
Author(s)
Deokjae Lee; Jungeun An; Young-Un Park; Hungjiun Liaw; Roger Woodgate; Jun Hong Park; Kyungjae Myung
Publication Date
2017-04
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-PHYSICAL SCIENCES, v.114, no.17, pp.E3424 - E3433
Publisher
NATL ACAD SCIENCES
Abstract
Many DNA repair proteins have additional functions other than their roles in DNA repair. In addition to catalyzing PCNA polyubiquitylation in response to the stalling of DNA replication, SHPRH has the additional function of facilitating rRNA transcription by localizing to the ribosomal DNA (rDNA) promoter in the nucleoli. SHPRH was recruited to the rDNA promoter using its plant homeodomain (PHD), which interacts with histone H3 when the fourth lysine of H3 is not trimethylated. SHPRH enrichment at the rDNA promoter was inhibited by cell starvation, by treatment with actinomycin D or rapamycin, or by depletion of CHD4. SHPRH also physically interacted with the RNA polymerase I complex. Taken together, we provide evidence that SHPRH functions in rRNA transcription through its interaction with histone H3 in a mammalian target of rapamycin (mTOR)-dependent manner.
URI
http://pr.ibs.re.kr/handle/8788114/4179
DOI
10.1073/pnas.1701978114
ISSN
0027-8424
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > Journal Papers (저널논문)
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