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면역미생물공생연구단
면역 미생물 공생 연구단
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CD8 alpha alpha intraepithelial lymphocytes arise from two main thymic precursors

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Title
CD8 alpha alpha intraepithelial lymphocytes arise from two main thymic precursors
Author(s)
Ruscher, R; Kummer, RL; You Jeong Lee; Jameson, SC; Hogquist, KA
Publication Date
2017-07
Journal
NATURE IMMUNOLOGY, v.18, no.7, pp.771 - 779
Publisher
NATURE PUBLISHING GROUP
Abstract
TCR alpha b(+)CD4(-)CD8 alpha(+)CD8 beta-intestinal intraepithelial lymphocytes (CD8 alpha alpha IELs) are an abundant population of thymus-derived T cells that protect the gut barrier surface. We sought to better define the thymic IEL precursor (IELp) through analysis of its maturation, localization and emigration. We defined two precursor populations among TCR beta(+)CD4(-)CD8(-) thymocytes by dependence on the kinase TAK1 and rigorous lineage-exclusion criteria. Those IELp populations included a nascent PD-1(+) population and a T-bet(+) population that accumulated with age. Both gave rise to intestinal CD8 alpha alpha IELs after adoptive transfer. The PD-1(+) IELp population included more strongly self-reactive clones and was largely restricted by classical major histocompatibility complex (MHC) molecules. Those cells localized to the cortex and efficiently emigrated in a manner dependent on the receptor S1PR1. The T-bet(+) IELp population localized to the medulla, included cells restricted by non-classical MHC molecules and expressed the receptor NK1.1, the integrin CD103 and the chemokine receptor CXCR3. The two IELp populations further differed in their use of the T cell antigen receptor (TCR) alpha-chain variable region (V-alpha) and beta-chain variable region (V-beta). These data provide a foundation for understanding the biology of CD8 alpha alpha IELs
URI
https://pr.ibs.re.kr/handle/8788114/4163
ISSN
1529-2908
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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