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뇌과학이미징연구단
뇌과학 이미징 연구단
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Chemical-exchange-sensitive MRI of amide, amine and NOE at 9.4T versus 15.2T

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Title
Chemical-exchange-sensitive MRI of amide, amine and NOE at 9.4T versus 15.2T
Author(s)
Julius Juhyun Chung; Wonmin Choi; Tao Jin; Jung Hee Lee; Seong‐Gi Kim
Publication Date
2017-09
Journal
NMR IN BIOMEDICINE, v.30, no.9, pp.e3740 -
Publisher
WILEY-BLACKWELL
Abstract
Chemical exchange (CE)-sensitive MRI benefits greatly from stronger magnetic fields; however, field effects on CE-sensitive imaging have not yet been studied well in vivo. We have compared CE-sensitive Z-spectra and maps obtained at the fields of 9.4T and 15.2T in phantoms and rats with off-resonance chemical-exchange-sensitive spin lock (CESL), which is similar to conventional chemical exchange saturation transfer. At higher fields, the background peak at water resonance has less spread and the exchange rate relative to chemical shift decreases, thus CESL intensity is dependent on B-0. For the in vivo amide and nuclear Overhauser enhancement (NOE) composite resonances of rat brains, intensities were similar for both magnetic fields, but effective amide proton transfer and NOE values obtained with three-point quantification or a curve fitting method were larger at 15.2T due to the reduced spread of attenuation at the direct water resonance. When using intermediate exchange-sensitive irradiation parameters, the amine proton signal was 65% higher at 15.2T than at 9.4T due to a reduced ratio of exchange rate to chemical shift. In summary, increasing magnetic field provides enhancements to CE-sensitive signals in the intermediate exchange regime and reduces contamination from background signals in the slow exchange regime. Consequently, ultrahigh magnetic field is advantageous for CE-sensitive MRI, especially for amine and hydroxyl protons. Copyright © 2017 John Wiley & Sons, Ltd.
URI
https://pr.ibs.re.kr/handle/8788114/4079
ISSN
0952-3480
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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