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Flow-suppressed hyperpolarized 13C chemical shift imaging using velocity-optimized bipolar gradient in mouse liver tumors at 9.4 T

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Title
Flow-suppressed hyperpolarized 13C chemical shift imaging using velocity-optimized bipolar gradient in mouse liver tumors at 9.4 T
Author(s)
Hansol Lee; Joonsung Lee; Eunhae Joe; Seungwook Yang; Jae Eun Song; Young-Suk Choi; EunkyungWang; Chan Gyu Joo; Ho-Taek Song; Dong-Hyun Kim
Publication Date
2017-11
Journal
MAGNETIC RESONANCE IN MEDICINE, v.78, no.5, pp.1674 - 1682
Publisher
WILEY-BLACKWELL
Abstract
Purpose: To optimize and investigate the influence of bipolar gradients for flow suppression in metabolic quantification of hyperpolarized 13C chemical shift imaging (CSI) of mouse liver at 9.4 T. Methods: The trade-off between the amount of flow suppression using bipolar gradients and T2 * effect from static spins was simulated. A free induction decay CSI sequence with alternations between the flow-suppressed and non–flow-suppressed acquisitions for each repetition time was developed and was applied to liver tumor–bearing mice via injection of hyperpolarized [1-13C] pyruvate. Results: The in vivo results from flow suppression using the velocity-optimized bipolar gradient were comparable with the simulation results. The vascular signal was adequately suppressed and signal loss in stationary tissue was minimized. Application of the velocity-optimized bipolar gradient to tumor-bearing mice showed reduction in the vessel-derived pyruvate signal contamination, and the average lactate/pyruvate ratio increased by 0.095 (P < 0.05) in the tumor region after flow suppression. Conclusion: Optimization of the bipolar gradient is essential because of the short 13C T2 * and high signal in venous flow in the mouse liver. The proposed velocity-optimized bipolar gradient can suppress the vascular signal, minimizing T2 *-related signal loss in stationary tissues at 9.4 T. Magn Reson Med 78:1674–1682, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicin
URI
https://pr.ibs.re.kr/handle/8788114/4068
ISSN
0740-3194
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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