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뇌과학이미징연구단
뇌과학 이미징 연구단
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Label-free nanoscale optical metrology on myelinated axons in vivo

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Title
Label-free nanoscale optical metrology on myelinated axons in vivo
Author(s)
Junhwan Kwon; Moonseok Kim; Hyejin Park; Bok-Man Kang; Yongjae Jo; Jae-Hwan Kim; Oliver James; Seok-Hyun Yun; Seong-Gi Kim; Minah Suh; Myunghwan Choi
Publication Date
2017-11
Journal
NATURE COMMUNICATIONS, v.8, no., pp.1832 -
Publisher
NATURE PUBLISHING GROUP
Abstract
In the mammalian nervous system, myelin provides electrical insulation for the neural circuit by forming a highly organized, multilayered thin film around the axon fibers. Here, we investigate the spectral reflectance from this subcellular nanostructure and devise a new label-free technique based on a spectroscopic analysis of reflected light, enabling nanoscale imaging of myelinated axons in their natural living state. Using this technique, we demonstrate three-dimensional mapping of the axon diameter and sensing of dynamic changes in the substructure of myelin at nanoscale. We further reveal the prevalence of axon bulging in the brain cortex in vivo after mild compressive trauma. Our novel tool opens new avenues of investigation by creating unprecedented access to the nanostructural dynamics of live myelinated axons in health and disease. © The Author(s) 2017
URI
http://pr.ibs.re.kr/handle/8788114/4065
DOI
10.1038/s41467-017-01979-2
ISSN
2041-1723
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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