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식물 노화·수명 연구단
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Multi-dimensional histone methylations for coordinated regulation of gene expression under hypoxia

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Title
Multi-dimensional histone methylations for coordinated regulation of gene expression under hypoxia
Author(s)
Seongyeol Lee; Jieon Lee; Sehyun Chae; Yunwon Moon; Ho-Youl Lee; Bongju Park; Eun Gyeong Yang; Daehee Hwang; Hyunsung Park
Publication Date
2017-11
Journal
NUCLEIC ACIDS RESEARCH, v.45, no.20, pp.11643 - 11657
Publisher
OXFORD UNIV PRESS
Abstract
Hypoxia increases both active and repressive histone methylation levels via decreased activity of histone demethylases. However, how such increases coordinately regulate induction or repression of hypoxia-responsive genes is largely unknown. Here, we profiled active and repressive histone tri-methylations (H3K4me3, H3K9me3, and H3K27me3) and analyzed gene expression profiles in human adipocyte-derived stem cells under hypoxia. We identified differentially expressed genes (DEGs) and differentially methylated genes (DMGs) by hypoxia and clustered the DEGs and DMGs into four major groups.We found that each group of DEGs was predominantly associated with alterations in only one type among the three histone tri-methylations. Moreover, the four groups of DEGs were associated with different TFs and localization patterns of their predominant types of H3K4me3, H3K9me3 and H3K27me3. Our results suggest that the association of altered gene expression with prominent singletype histone tri-methylations characterized by different localization patterns and with different sets of TFs contributes to regulation of particular sets of genes, which can serve as a model for coordinated epigenetic regulation of gene expression under hypoxia. The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.
URI
http://pr.ibs.re.kr/handle/8788114/4033
DOI
10.1093/nar/gkx747
ISSN
0305-1048
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
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