BROWSE

Related Scientist

kim,doyoun's photo.

kim,doyoun
시냅스뇌질환연구단
more info

ITEM VIEW & DOWNLOAD

LAR-rptp clustering is modulated by competitive binding between synaptic adhesion partners and heparan sulfate

Cited 14 time in webofscience Cited 14 time in scopus
1,083 Viewed 566 Downloaded
Title
LAR-rptp clustering is modulated by competitive binding between synaptic adhesion partners and heparan sulfate
Author(s)
Seoung Youn Won; Cha Yeon Kim; Doyoun Kim; Jaewon Ko; Ji Won Um; Sung Bae Lee; Matthias Buck; Eunjoon Kim; Won Do Heo; Jie-Oh Lee; Ho Min Kim
Subject
Crystal structure, ; Heparin sulfate, ; Higher-order clustering, ; LAR-RPTPs, ; Postsynaptic ligand, ; Synaptic adhesion molecules
Publication Date
2017-10
Journal
FRONTIERS IN MOLECULAR NEUROSCIENCE, v.10, pp.327
Publisher
FRONTIERS MEDIA SA
Abstract
The leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that direct axonal growth and neuronal regeneration. LAR-RPTPs are also synaptic adhesion molecules that form trans-synaptic adhesion complexes by binding to various postsynaptic adhesion ligands, such as Slit- and Trk-like family of proteins (Slitrks), IL-1 receptor accessory protein-like 1 (IL1RAPL1), interleukin-1 receptor accessory protein (IL-1RAcP) and neurotrophin receptor tyrosine kinase C (TrkC), to regulate synaptogenesis. Here, we determined the crystal structure of the human LAR-RPTP/IL1RAPL1 complex and found that lateral interactions between neighboring LAR-RPTP/IL1RAPL1 complexes in crystal lattices are critical for the higher-order assembly and synaptogenic activity of these complexes. Moreover, we found that LAR-RPTP binding to the postsynaptic adhesion ligands, Slitrk3, IL1RAPL1 and IL-1RAcP, but not TrkC, induces reciprocal higher-order clustering of trans-synaptic adhesion complexes. Although LAR-RPTP clustering was induced by either HS or postsynaptic adhesion ligands, the dominant binding of HS to the LAR-RPTP was capable of dismantling pre-established LAR-RPTP-mediated trans-synaptic adhesion complexes. These findings collectively suggest that LAR-RPTP clustering for synaptogenesis is modulated by a complex synapse-organizing protein network. © 2017 Won, Kim, Kim, Ko, Um, Lee, Buck, Kim, Heo, Lee and Kim.
URI
https://pr.ibs.re.kr/handle/8788114/4007
DOI
10.3389/fnmol.2017.00327
ISSN
1662-5099
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
20171013 Frontiers in Molecular Neuroscience.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse