Reducing Agent-Assisted Excessive Galvanic Replacement Mediated Seed-Mediated Synthesis of Porous Gold Nanoplates and Highly Efficient Gene-Thermo Cancer Therapy

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Title
Reducing Agent-Assisted Excessive Galvanic Replacement Mediated Seed-Mediated Synthesis of Porous Gold Nanoplates and Highly Efficient Gene-Thermo Cancer Therapy
Author(s)
Seounghun Kang; Kyunglee Kang; Hyun Huh; Hyungjun Kim; Sung-Jin Chang; Tae Jung Park; Ki Soo Chang; Dal-Hee Min; Hongje Jang
Publication Date
2017-10
Journal
ACS APPLIED MATERIALS & INTERFACES, v.9, no.40, pp.35268 - 35278
Publisher
AMER CHEMICAL SOC
Abstract
Porous Au nanoplates (pAuNPs) were manufactured by a reducing agent-assisted galvanic replacement reaction on Ag nanoplates using a seed-mediated synthetic approach. Two core additives, poly(vinylpyrrolidone) and ,ascorbic acid, prevented fragmentation and proceeded secondary growth. By controlling the concentration of the additives and the amount of replacing ion AuCl4-, various nanostructures including nanoplates with holes, nanoframes, porous nanoplates, and bumpy nanoparticles with unity and homogeneity were synthesized. The present synthetic method is advantageous, because it can be used to manufacture pAuNPs with ease, robustness, and convenience. The prepared pAuNPs exhibited a highly efficient photothermal conversion effect and cargo loading capacity on exposed surfaces by Au-thiol linkage. By using dual cargo mixed loading of the hepatitis C virus (HCV) targeting gene drug DNAzyme and cell-penetrating peptide TAT onto the surface of the pAuNPs and photothermal conversion-mediated hyperthermic treatment, successful gene-thermo therapy against HCV genomic human hepatocarcinoma cells were demonstrated. © 2017 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/4006
ISSN
1944-8244
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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