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Thalamic Spindles Promote Memory Formation during Sleep through Triple Phase-Locking of Cortical, Thalamic, and Hippocampal RhythmsHighly Cited Paper

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dc.contributor.authorCharles-Francois V. Latchoumane-
dc.contributor.authorHong-Viet V. Ngo-
dc.contributor.authorJan Born-
dc.contributor.authorHee-Sup Shin-
dc.date.available2017-11-10T04:53:27Z-
dc.date.created2017-08-29-
dc.date.issued2017-07-
dc.identifier.issn0896-6273-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/3987-
dc.description.abstractWhile the interaction of the cardinal rhythms of non-rapid-eye-movement (NREM) sleep-the thalamocortical spindles, hippocampal ripples, and the cortical slow oscillations-is thought to be critical for memory consolidation during sleep, the role spindles play in this interaction is elusive. Combining optogenetics with a closed-loop stimulation approach in mice, we show here that only thalamic spindles induced in-phase with cortical slow oscillation upstates, but not out-of-phase-induced spindles, improve consolidation of hippocampus-dependent memory during sleep. Whereas optogenetically stimulated spindles were as efficient as spontaneous spindles in nesting hippocampal ripples within their excitable troughs, stimulation in-phase with the slow oscillation up-state increased spindle co-occurrence and frontal spindle-ripple co-occurrence, eventually resulting in increased triple coupling of slow oscillation-spindle-ripple events. In-phase optogenetic suppression of thalamic spindles impaired hippocampus-dependent memory. Our results suggest a causal role for thalamic sleep spindles in hippocampus-dependent memory consolidation, conveyed through triple coupling of slow oscillations, spindles, and ripples. (c) 2017 Elsevier Inc.-
dc.description.uri1-
dc.language영어-
dc.publisherCELL PRESS-
dc.titleThalamic Spindles Promote Memory Formation during Sleep through Triple Phase-Locking of Cortical, Thalamic, and Hippocampal Rhythms-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000405857500018-
dc.identifier.scopusid2-s2.0-85021793353-
dc.identifier.rimsid59986ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorCharles-Francois V. Latchoumane-
dc.contributor.affiliatedAuthorHee-Sup Shin-
dc.identifier.doi10.1016/j.neuron.2017.06.025-
dc.identifier.bibliographicCitationNEURON, v.95, no.2, pp.424 - 435-
dc.citation.titleNEURON-
dc.citation.volume95-
dc.citation.number2-
dc.citation.startPage424-
dc.citation.endPage435-
dc.date.scptcdate2018-10-01-
dc.description.wostc13-
dc.description.scptc20-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusCLOSED-LOOP STIMULATION-
dc.subject.keywordPlusSLOW-WAVE SLEEP-
dc.subject.keywordPlusENHANCES MEMORY-
dc.subject.keywordPlusTRANSGENIC MICE-
dc.subject.keywordPlusCONSOLIDATION-
dc.subject.keywordPlusOSCILLATIONS-
dc.subject.keywordPlusRIPPLES-
dc.subject.keywordPlusHUMANS-
dc.subject.keywordPlusDEPRIVATION-
dc.subject.keywordPlusPLASTICITY-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > Social Neuroscience Group(사회성 뇌과학 그룹) > 1. Journal Papers (저널논문)
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